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Closed Access item Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity

Authors:Esteban, J. A.
Keywords:AMPA-type glutamate receptors, Long-term depression (LTD), Long-term potentiation (LTP), Synaptic function
Issue Date:2008
Citation:Synaptic Plasticity and the Mechanism of Alzheimer's Disease Research and Perspectives in Alzheimer’s Disease, 19-35 (2008)
Abstract:AMPA-type glutamate receptors are among the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses lead to long-lasting forms of synaptic plasticity, known as long-term potentiation (LTP) and long-term depression (LTD). In addition, AMPA receptors (AMPARs) reach their synaptic targets after a complicated journey involvingmultiple transport steps through different membrane compartments. This chapter summarizes our current knowledge of the trafficking pathways of AMPARs and their relation to synaptic function and plasticity.
Publisher version (URL):http://dx.doi.org/10.1007/978-3-540-76330-7
Appears in Collections:(CBM) Libros y Partes de Libros

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