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Title: Transcription regulation in Bacillus subtilis phage Φ29
Authors: Rojo, Fernando, Barthelemy, Isabel, Nuez, B., Serrano, M., Salas, Margarita
Keywords: Bacillus subtilis
DNA
Bacteriophage phi29
Transcription'
Issue Date: 1991
Abstract: The molecular biology of Bacillus subtllis phage e~29 has been extensively studied and now stands among the best known phages infecting Grampositive bacteria. As a resait, it has become a model system for the study of proteln-primed DNA replication (Salas, 1991)and phage particle morphogenesis (Casjens and Hendrlx, 1988). The tight control in the expression of the different genes involved in these two processes also make it an interesting model for the study of transcription regulation. At early periods of infection, only the genes involved in DNA replication and transcription regulation are expressed. Genes coding for structural components of the phage particle, or for proteins involved in morphogenesis and cell lysis, are transcribed at later stages of infection, when DNA replication is well advanced. Early genes are all coded by the same DNA strand and are located at both ends of the genome (lneiarte el al,, 1976; Mellado et al., 1976; see fig. l). Late genes are coded by the complementary strand and are clustered in the central part of the genome, a linear molecule 19285 bp long (Vl,~ek and Paces, 1986) witi~ the viral terminal protein p3 covalemly linked at both 5' ends (Salas et at., 1978).
Publisher version (URL): http://dx.doi.org/10.1016/0923-2508(91)90054-E
URI: http://hdl.handle.net/10261/40030
ISSN: 0923-2508
1769-7123
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Citation: Research in Microbiology 142(7-8):771-777(1991)
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