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Título : Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Autor : Hayashi, Yasunori, Shi, Song-Hai, Esteban, José A., Piccini, Antonella, Poncer, Jean-Christophe, Malinow, Roberto
Palabras clave : Long-term potentiation
Synaptic receptors
Fecha de publicación : 24-Mar-2000
Editor: American Association for the Advancement of Science
Resumen: To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons. Long-term potentiation (LTP) or increased activity of the calcium/ calmodulin-dependent protein kinase II (CaMKII) induced delivery of tagged AMPA-Rs into synapses. This effect was not diminished by mutating the CaMKII phosphorylation site on the GluR1 AMPA-R subunit, but was blocked by mutating a predicted PDZ domain interaction site. These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
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ISSN: 0036-8075
DOI: 10.1126/science.287.5461.2262
Citación : Science 287: 2262 (2010)
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