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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/39886
Title: Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction
Authors: Hayashi, Yasunori; Shi, Song-Hai; Esteban, José A.; Piccini, Antonella; Poncer, Jean-Christophe; Malinow, Roberto
Keywords: Long-term potentiation
Synaptic receptors
Issue Date: 24-Mar-2000
Publisher: American Association for the Advancement of Science
Citation: Science 287: 2262 (2010)
Abstract: To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons. Long-term potentiation (LTP) or increased activity of the calcium/ calmodulin-dependent protein kinase II (CaMKII) induced delivery of tagged AMPA-Rs into synapses. This effect was not diminished by mutating the CaMKII phosphorylation site on the GluR1 AMPA-R subunit, but was blocked by mutating a predicted PDZ domain interaction site. These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Publisher version (URL): http://dx.doi.org/10.1126/science.287.5461.2262
URI: http://hdl.handle.net/10261/39886
ISSN: 0036-8075
DOI: 10.1126/science.287.5461.2262
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