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Closed Access item Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

Authors:Hayashi, Yasunori
Shi, Song-Hai
Esteban, J. A.
Piccini, Antonella
Poncer, Jean-Christophe
Malinow, Roberto
Keywords:Long-term potentiation, CaMKII, Synaptic receptors
Issue Date:24-Mar-2000
Publisher:American Association for the Advancement of Science
Citation:Science 287: 2262 (2010)
Abstract:To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, a-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag were expressed in rat hippocampal neurons. Long-term potentiation (LTP) or increased activity of the calcium/ calmodulin-dependent protein kinase II (CaMKII) induced delivery of tagged AMPA-Rs into synapses. This effect was not diminished by mutating the CaMKII phosphorylation site on the GluR1 AMPA-R subunit, but was blocked by mutating a predicted PDZ domain interaction site. These results show that LTP and CaMKII activity drive AMPA-Rs to synapses by a mechanism that requires the association between GluR1 and a PDZ domain protein.
Publisher version (URL):http://dx.doi.org/10.1126/science.287.5461.2262
URI:http://hdl.handle.net/10261/39886
ISSN:0036-8075
Appears in Collections:(CBM) Artículos

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