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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/39676
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dc.contributor.authorMolina-Guijarro, José M.-
dc.contributor.authorMacías, Álvaro-
dc.contributor.authorGarcía Rodríguez, Carolina-
dc.contributor.authorMuñoz, Eva-
dc.contributor.authorGarcía-Fernández, Luis F.-
dc.contributor.authorDavid, Miren-
dc.contributor.authorNúñez, Lucía-
dc.contributor.authorLillo, M. Pilar-
dc.contributor.authorVillalobos, Carlos-
dc.contributor.authorValenzuela, Carmen-
dc.date.accessioned2011-09-19T11:31:24Z-
dc.date.available2011-09-19T11:31:24Z-
dc.date.issued2011-04-27-
dc.identifier.citationPLoS ONE 6(4): e19402 (2011)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/39676-
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License.-- et al.-
dc.description.abstractIrvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significant Ca(2+) influx, perturbations of membrane conductivity, severe swelling and the formation of giant membranous vesicles. All these effects are not observed in Irvalec-resistant cells, or are significantly delayed by pretreating the cells with Zn(2+). Using fluorescent derivatives of Irvalec it was demonstrated that the compound rapidly interacts with the plasma membrane of tumor cells promoting lipid bilayer restructuration. Also, FRET experiments demonstrated that Irvalec molecules localize in the cell membrane close enough to each other as to suggest that the compound could self-organize, forming supramolecular structures that likely trigger cell death by necrosis through the disruption of membrane integrity.es_ES
dc.description.sponsorshipThis work was supported by Ministerio de Ciencia e Innovación (MICINN), Spain (SAF2007-65868, SAF2010-14916, Red Cooperativa de Enfermedades Cardiovasculares RECAVA FIS RD06/0014/0006 to CV, PIF200680F0023, S-BIO-0260/2006, CTQ 2009-12412 to MPL). MD and AM hold RECAVA contract and JAEPredoc Grant, respectively.-
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's version-
dc.rightsopenAccesses_ES
dc.subjectKahalalide-fes_ES
dc.subjectHkv1.5 channelses_ES
dc.subjectBlockes_ES
dc.subjectCanceres_ES
dc.titleIrvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cellses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0019042-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0019042es_ES
dc.identifier.e-issn1932-6203-
dc.identifier.pmid21556352-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
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