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Título : Histone H1 Poly[ADP]-Ribosylation Regulates the Chromatin Alterations Required for Learning Consolidation
Autor : Fontán-Lozano, Ángela, Suárez-Pereira, Irene, Horrillo, Angélica, Pozo-Martín, Yaiza del, Hmadcha, Abdelkrim, Carrión, Ángel Manuel
Fecha de publicación : Oct-2010
Editor: Society for Neuroscience
Resumen: Memory formation requires changes in gene expression, which are regulated by the activation of transcription factors and by changes in epigenetic factors. Poly[ADP]-ribosylation of nuclear proteins has been postulated as a chromatin modification involved in memory consolidation, although the mechanisms involved are not well characterized. Here we demonstrate that poly[ADP]-ribose polymerase 1 (PARP-1) activity and the poly[ADP]-ribosylation of proteins over a specific time course is required for the changes in synaptic plasticity related to memory stabilization in mice. At the molecular level, histone H1 poly[ADP]-ribosylation was evident in the hippocampus after the acquisition period, and it was selectively released in a PARP-1-dependent manner at the promoters of cAMP response element-binding protein and nuclear factor-κB dependent genes associated with learning and memory. These findings suggest that histone H1 poly[ADP]-ribosylation, and its loss at specific loci, is an epigenetic mechanism involved in the reprogramming of neuronal gene expression required for memory consolidation.
Descripción : 9 páginas, 6 figuras.
Versión del editor:​JNEUROSCI.3010-10.2010
DOI: 10.1523/​JNEUROSCI.3010-10.2010
Citación : Journal of Neuroscience 30(40): 13305-13313 (2010)
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