English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/38970
Title: Histone H1 Poly[ADP]-Ribosylation Regulates the Chromatin Alterations Required for Learning Consolidation
Authors: Fontán-Lozano, Ángela; Suárez-Pereira, Irene; Horrillo, Angélica; Pozo-Martín, Yaiza del; Hmadcha, Abdelkrim; Carrión, Ángel Manuel
Issue Date: Oct-2010
Publisher: Society for Neuroscience
Citation: Journal of Neuroscience 30(40): 13305-13313 (2010)
Abstract: Memory formation requires changes in gene expression, which are regulated by the activation of transcription factors and by changes in epigenetic factors. Poly[ADP]-ribosylation of nuclear proteins has been postulated as a chromatin modification involved in memory consolidation, although the mechanisms involved are not well characterized. Here we demonstrate that poly[ADP]-ribose polymerase 1 (PARP-1) activity and the poly[ADP]-ribosylation of proteins over a specific time course is required for the changes in synaptic plasticity related to memory stabilization in mice. At the molecular level, histone H1 poly[ADP]-ribosylation was evident in the hippocampus after the acquisition period, and it was selectively released in a PARP-1-dependent manner at the promoters of cAMP response element-binding protein and nuclear factor-κB dependent genes associated with learning and memory. These findings suggest that histone H1 poly[ADP]-ribosylation, and its loss at specific loci, is an epigenetic mechanism involved in the reprogramming of neuronal gene expression required for memory consolidation.
Description: 9 páginas, 6 figuras.
Publisher version (URL): http://dx.doi.org/10.1523/​JNEUROSCI.3010-10.2010
URI: http://hdl.handle.net/10261/38970
DOI: 10.1523/​JNEUROSCI.3010-10.2010
E-ISSN: 1529-2401
Appears in Collections:(CABIMER) Artículos
Files in This Item:
File Description SizeFormat 
ARTICULOS23263[1].pdf1,17 MBAdobe PDFView/Open
Show full item record
Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.