Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/38869
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorSánchez-Hidalgo, Marina-
dc.contributor.authorAlarcón de la Lastra, Catalina-
dc.contributor.authorCarrascosa-Salmoral, M. P.-
dc.contributor.authorNaranjo, M. C.-
dc.contributor.authorGómez-Corvera, A.-
dc.contributor.authorCaballero, B.-
dc.contributor.authorGuerrero Montávez, Juan Miguel-
dc.date.accessioned2011-08-24T07:48:45Z-
dc.date.available2011-08-24T07:48:45Z-
dc.date.issued2009-02-20-
dc.identifier.citationExperimental Gerontology 44(5): 328-334 (2009)es_ES
dc.identifier.issn0531-5565-
dc.identifier.otherPMID:19233254-
dc.identifier.urihttp://hdl.handle.net/10261/38869-
dc.description7 páginas, 5 figuras, 1 tabla.es_ES
dc.description.abstractIn the search of new therapeutic targets improving the quality of life of elderly, melatonin, “the chemical expression of darkness”, seems to play a remarkable role in aging process possibly due to its antioxidant, immunoenhancer and anti-aging properties. The present study was designed to elucidate effects of aging in melatonin extrapineal synthesis and investigate evident age-related alterations in the action mechanisms involved. The presence of the two key enzymes involved in melatonin synthesis, arylalkylamine-N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT) was analyzed in thymus, spleen, liver, kidney and heart of 3- and 12 month-old rats using real time PCR as well as its functionality by enzymatic activity assays. In addition, extrapineal melatonin content was measured by a competitive enzyme immunoassay (ELISA). The results of this study reveal that all rat tissues studied including thymus, and for the first time, spleen, liver, kidney and heart have the necessary machinery to synthesize melatonin. Moreover, we report an age-related decline in rat extrapineal melatonin synthesis with a consequent HIOMT functionality decrease in spleen, liver and heart during physiological aging. On the contrary, NAT enzymatic activity maintains unchanged without evident alterations with advancing age. Moreover, diminished melatonin concentrations were measured in these tissues cited above during aging except in the thymus, where, surprisingly, melatonin content, NAT/HIOMT expression, and enzymatic functionality assays revealed no significant alterations with age. As a conclusion, we report evident age-related changes in melatonin synthesis in some rat peripheral organs. We suggest that thymus may develop compensatory mechanisms to counteract the loss of immune activity and consequently, the loss of this potent antioxidant, during physiological aging.es_ES
dc.description.sponsorshipThis work was supported by grants of the Andalucía (P06-CTS-1604) and Spanish (PI 060091; RD06/00130001) governments. MSH gratefully acknowledges support from a Postgraduate National Program of FPU fellowship and financial sponsorship from the Spanish MEC.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectExtrapineal melatonines_ES
dc.subjectNATes_ES
dc.subjectHIOMTes_ES
dc.subjectAginges_ES
dc.subjectNeuroimmunomodulationes_ES
dc.titleAge-related changes in melatonin synthesis in rat extrapineal tissueses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.exger.2009.02.002-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.exger.2009.02.002es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
Aparece en las colecciones: (IBIS) Artículos
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

104
checked on 22-mar-2024

WEB OF SCIENCETM
Citations

95
checked on 21-feb-2024

Page view(s)

535
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.