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Título: | A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity |
Autor: | Hudson, James D.; Shoaibi, Mahmood A.; Maestro, Roberta; Carnero, Amancio CSIC ORCID; Hannon, Gregory J.; Beach, David H. | Palabras clave: | Macrophage migration inhibitory factor Tumor suppressor Protein p53 Inflammation Cancer Growth arrest Apoptosis Fibroblasts Mice Nitric oxide |
Fecha de publicación: | 15-nov-1999 | Editor: | Rockefeller University Press | Citación: | Journal of Experimental Medicine 190(10): 1375-1382 (1999) | Resumen: | p53 has a key role in the negative regulation of cell proliferation, in the maintenance of genomic stability, and in the suppression of transformation and tumorigenesis. To identify novel regulators of p53, we undertook two functional screens to isolate genes which bypassed either p53-mediated growth arrest or apoptosis. In both screens, we isolated cDNAs encoding macrophage migration inhibitory factor (MIF), a cytokine that was shown previously to exert both local and systemic proinflammatory activities. Treatment with MIF overcame p53 activity in three different biological assays, and suppressed its activity as a transcriptional activator. The observation that a proinflammatory cytokine, MIF, is capable of functionally inactivating a tumor suppressor, p53, may provide a link between inflammation and tumorigenesis. | Descripción: | 8 páginas, 5 figuras. | Versión del editor: | http://jem.rupress.org/content/190/10/1375.full | URI: | http://hdl.handle.net/10261/38827 | ISSN: | 0022-1007 | E-ISSN: | 1540-9538 |
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