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Open Access item Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans

Authors:Lasala, Fátima
Arce, Eva
Otero, Joaquín R.
Rojo Marcos, Francisco Javier
Delgado, R.
Keywords:Antiviral Agents, Cell adhesion molecules, Drug desing, Ebola virus, Lectins, C-type, Mannans, Viral envelope proteins, Stereoisomerism
Issue Date:Dec-2003
Publisher:American Society for Microbiology
Citation:Antimicrobial Agents and Chemotherapy 47(12): 3970-3972 (2003)
Abstract:We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.
Description:3 páginas, 3 figuras.
Publisher version (URL):http://dx.doi.org/10.1128/AAC.47.12.3970–3972.2003
E-ISSNmetadata.dc.identifier.doi = DOI:1098-6596
Appears in Collections:(IIQ) Artículos

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