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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/38545
Title: Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans
Authors: Lasala, Fátima; Arce, Eva; Otero, Joaquín R.; Rojo, Javier; Delgado, R.
Keywords: Antiviral Agents
Cell adhesion molecules
Drug desing
Ebola virus
Lectins, C-type
Viral envelope proteins
Issue Date: Dec-2003
Publisher: American Society for Microbiology
Citation: Antimicrobial Agents and Chemotherapy 47(12): 3970-3972 (2003)
Abstract: We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.
Description: 3 páginas, 3 figuras.
Publisher version (URL): http://dx.doi.org/10.1128/AAC.47.12.3970–3972.2003
URI: http://hdl.handle.net/10261/38545
DOI: 10.1128/AAC.47.12.3970–3972.2003
ISSN: 0066-4804
E-ISSN: 1098-6596
References: PMC296220
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