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Título : Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans
Autor : Lasala, Fátima, Arce, Eva, Otero, Joaquín R., Rojo Marcos, Francisco Javier, Delgado, R.
Palabras clave : Antiviral Agents
Cell adhesion molecules
Drug desing
Ebola virus
Lectins, C-type
Mannans
Viral envelope proteins
Stereoisomerism
Fecha de publicación : Dec-2003
Editor: American Society for Microbiology
Citación : Antimicrobial Agents and Chemotherapy 47(12): 3970-3972 (2003)
Resumen: We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.
Descripción : 3 páginas, 3 figuras.
Versión del editor: http://dx.doi.org/10.1128/AAC.47.12.3970–3972.2003
URI : http://hdl.handle.net/10261/38545
ISSN: 0066-4804
DOI: 10.1128/AAC.47.12.3970–3972.2003
Citación : Antimicrobial Agents and Chemotherapy 47(12): 3970-3972 (2003)
Referencias: PMC296220
PMID:14638512
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