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Title

A Metal-free, Three-component Manifold for the C2-Functionalization of 1-Substituted Imidazoles Operating "On Water"

AuthorsCruz-Acosta, Fabio ; Armas, Pedro de ; García-Tellado, Fernando
KeywordsNitrogen heterocycles
Carbenes
Ylides
Multicomponent reactions
Water
Issue Date2010
PublisherThieme
CitationSynlett 16: 2421-2424 (2010)
AbstractA metal-free, three-component process for the C2-functionalization of N-alkylated imidazoles is reported The multicomponent manifold operates under ‘on water' conditions through the formation of a water-stable (permanent) nucleophilic imidazole carbene (imidazolium ylide). Whereas the incorporated vinyl ether functionality is a convenient handle for further chemical manipulation of the functionalized heterocycle (complexity generation), the use of water as the reaction media gives it a bonus of added benefits in terms of safety, bench-friendly processing and environmental care.
Description5 páginas, 2 tablas, 2 esquemas, 3 ecuaciones.-- El PDF es la versión de autor.
Publisher version (URL)http://dx.doi.org/10.1055/s-0030-1258561
URIhttp://hdl.handle.net/10261/38411
DOI10.1055/s-0030-1258561
ISSN0936-5214
Appears in Collections:(IPNA) Artículos
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