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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37997
Title: Citrate inhibition of phosphofructokinase and the Pasteur effect
Authors: Salas, María Luisa; Viñuela, Eladio; Salas, Margarita; Sols, Alberto
Issue Date: 1965
Publisher: Elsevier
Citation: Biochemical and Biophysical Research Communications 19(3): 371-376 (1965)
Abstract: A large amount of recent evidence clearly indicates that the regulation of phosphofructokinase (PFK) activity is fundamental in the control of glycolysis (Lowry and Passonneau, 1964) through a series of feedback mechanisms (Sols et., 1963). Endproduct inhibition of PFK by ATP (ViRuela et. , 1963) may account for the Pasteur effect in certain tissues (Wu, 1964) . Nevertheless, it has been reported that in glucose utilizing yeast, where both the Pasteur effect and an involvement of PFK in it were first observ - ed, the level of ATP is essentially the same in aerobiosis and an- aerobiosis (1-ynen et. , 1959) . Evidence reported here indicates that an additional feedback inhibition involving citrate may account for the aerobic regulation of PFK activity in yeast.
Publisher version (URL): http://dx.doi.org/10.1016/0006-291X(65)90471-7
URI: http://hdl.handle.net/10261/37997
DOI: 10.1016/0006-291X(65)90471-7
ISSN: 0006-291X
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