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Título : Citrate inhibition of phosphofructokinase and the Pasteur effect
Autor : Salas, María L., Viñuela, Eladio, Salas, Margarita, Sols, Alberto
Fecha de publicación : 1965
Editor: Elsevier
Citación : Biochemical and Biophysical Research Communications 19(3): 371-376 (1965)
Resumen: A large amount of recent evidence clearly indicates that the regulation of phosphofructokinase (PFK) activity is fundamental in the control of glycolysis (Lowry and Passonneau, 1964) through a series of feedback mechanisms (Sols et., 1963). Endproduct inhibition of PFK by ATP (ViRuela et. , 1963) may account for the Pasteur effect in certain tissues (Wu, 1964) . Nevertheless, it has been reported that in glucose utilizing yeast, where both the Pasteur effect and an involvement of PFK in it were first observ - ed, the level of ATP is essentially the same in aerobiosis and an- aerobiosis (1-ynen et. , 1959) . Evidence reported here indicates that an additional feedback inhibition involving citrate may account for the aerobic regulation of PFK activity in yeast.
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ISSN: 0006-291X
DOI: 10.1016/0006-291X(65)90471-7
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