Biología y Biomedicina >
Centro de Biología Molecular Severo Ochoa (CBM) >
(CBM) Artículos >
Closed Access item Glucokinase of rabbit liver: purification and properties
|Publisher:||American Society for Biochemistry and Molecular Biology|
|Citation:||The Journal of Biological Chemistry 240: 1014-1018 (1965)|
|Abstract:||It has been recently shown that in rat liver there are two
enzymes which phosphorylate glucose to glucose 6-phosphate.
One o f them is a hexokinase with a great af f ini ty for glucose and,
like those o f other animal tissues it is inhibited by glucose 6-
phosphate; the other one, named glucokinase, has a low affinity
for glucose, is not inhibited by glucose 6phosphate, and appears
to be responsible for glycogen synthesis from glucose in liver (1).
Hexokinase activity exists in both fetal and adult liver whereas
glucokinase develops after birth (2). Results from several
laboratories have shown that glucokinase activity disappears as a
result of fasting and diabet,es and reappears after refeeding or
insulin administration, respectively (l-9), and that this reap-
pearance involves synthesis de nouo of the enzyme apparently
mediated by insulin (3, 4, 6, 10)|
|Publisher version (URL):||http://hwmaint.jbc.org/cgi/reprint/240/3/1014|
|Appears in Collections:||(CBM) Artículos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.