DSpace

Digital.CSIC > Biología y Biomedicina > Centro de Biología Molecular Severo Ochoa (CBM) > (CBM) Artículos >

Share

EndNote

Impact

Links

Closed Access item Muscle fructose-1, 6-diphosphatase

Authors:Salas, Margarita
Viñuela, Eladio
Sols, Alberto
Issue Date:17-Feb-1965
Publisher:American Society for Biochemistry and Molecular Biology
Citation:The Journal of Biological Chemistry 17(2): 150-155 (1964)
Abstract:Fructose-1, 6-diphosphatase (FDPase), a key enzyme in neoglycogenesis, is generally considered as essentially restricted to liver and kidney although a small activity had been early detected in skeletal muscle (Gomori 1943; Hers and Vanden Berghe 1957). Interest in the regulation of the activity of FDPase has been recently aroused by studies with liver and kidney preparations (Taketa and Pogell 1963; Mendicino and Vasarhely 1963; Krebs 1964 a; Newsholme 1963). This communication reports the occurrence of significant amounts of FDPase in skeletal muscle of frog and rabbit. The frog muscle enzyme has a very great affinity for fructose-1, 6-P (FDP) as substrate and for AMP as allosteric inhibitor. The possible physiological significance of these kinetic properties and of the occurrence of this enzyme in muscle is discussed.
Publisher version (URL):http://dx.doi.org/10.1016/0006-291X(64)90136-6
URI:http://hdl.handle.net/10261/37865
ISSN:0021-9258
10.1016/0006-291X(64)90136-6
Appears in Collections:(CBM) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.