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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37865
Title: Muscle fructose-1, 6-diphosphatase
Authors: Salas, Margarita; Viñuela, Eladio; Sols, Alberto
Issue Date: 17-Feb-1965
Publisher: American Society for Biochemistry and Molecular Biology
Citation: The Journal of Biological Chemistry 17(2): 150-155 (1964)
Abstract: Fructose-1, 6-diphosphatase (FDPase), a key enzyme in neoglycogenesis, is generally considered as essentially restricted to liver and kidney although a small activity had been early detected in skeletal muscle (Gomori 1943; Hers and Vanden Berghe 1957). Interest in the regulation of the activity of FDPase has been recently aroused by studies with liver and kidney preparations (Taketa and Pogell 1963; Mendicino and Vasarhely 1963; Krebs 1964 a; Newsholme 1963). This communication reports the occurrence of significant amounts of FDPase in skeletal muscle of frog and rabbit. The frog muscle enzyme has a very great affinity for fructose-1, 6-P (FDP) as substrate and for AMP as allosteric inhibitor. The possible physiological significance of these kinetic properties and of the occurrence of this enzyme in muscle is discussed.
Publisher version (URL): http://dx.doi.org/10.1016/0006-291X(64)90136-6
URI: http://hdl.handle.net/10261/37865
DOI: 10.1016/0006-291X(64)90136-6
ISSN: 0021-9258
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