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Closed Access item Insulin-dependent synthesis of liver glucokinase in the rat

Authors:Salas, Margarita
Viñuela, Eladio
Sols, Alberto
Issue Date:1963
Publisher:American Society for Biochemistry and Molecular Biology
Citation:The Journal of Biological Chemistry 238: 3535-3538 (1963)
Abstract:A glucokinase qualitatively and quantitatively adequate as the first and limiting step in the synthesis of glycogen from glucose has been recently identified in the liver of the normal fed rat. In contrast with hexokinase, glucokinase activity was found to disappear in fasted and alloxan-diabetic animals (1). A characteristic shared by deprivation of food and diabetes is the marked decrease of insulin secretion and a very low level of free insulin in plasma (2, 3). Insulin could control either the activity of the glucokinase or its synthesis. The results here described suggest that the synthesis of the enzyme is insulin-dependent. No hormonal effect on its activity has been detected
URI:http://hdl.handle.net/10261/37858
ISSN:0021-9258
Appears in Collections:(CBM) Artículos

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