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dc.contributor.authorNarasimhan, Meena L.-
dc.contributor.authorDamsz, Barbara-
dc.contributor.authorCoca, María-
dc.contributor.authorIbeas, José I.-
dc.contributor.authorYun, Dae-Jin-
dc.contributor.authorPardo, José M.-
dc.contributor.authorHasegawa, Paul M.-
dc.contributor.authorBressan, Ray A.-
dc.date.accessioned2011-07-14T13:07:29Z-
dc.date.available2011-07-14T13:07:29Z-
dc.date.issued2001-10-26-
dc.identifier.citationMolecular Cell 8(4): 921-930 (2001)es_ES
dc.identifier.issn1097-2765-
dc.identifier.urihttp://hdl.handle.net/10261/37774-
dc.description10 pages, 1 table, 6 figures, 56 references.es_ES
dc.description.abstractOsmotin is a tobacco PR-5 protein that has antifungal activity and is implicated in host-plant defense. We show here that osmotin induces apoptosis in Saccharomyces cerevisiae. Induction of apoptosis was correlated with intracellular accumulation of reactive oxygen species and was mediated by RAS2, but not RAS1. Osmotin treatment resulted in suppression of transcription of stress-responsive genes via the RAS2/cAMP pathway. It was therefore concluded that osmotin induced proapoptotic signaling in yeast. The results indicate that the ability of antimicrobial proteins to induce microbial apoptosis could be an important factor in determining a pathogen's virulence and could therefore be targeted for the design of new antifungal drugs.es_ES
dc.description.sponsorshipThis work was supported in part by funds from the NSF Award No. 9808551-MCB, USDA Cooperative Research Program, USDA Award No. 96-34339-3484, Bard Project No. IS-2610-95CR, and Purdue University Agricultural Experiment Station. J. I. I. was supported by a Spanish Government Fellowship. This is journal paper number 16,471 of the Purdue University Agricultural Experiment Station.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.titleA plant defense response effector induces microbial apoptosises_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/S1097-2765(01)00365-3-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/doi:10.1016/S1097-2765(01)00365-3es_ES
dc.contributor.funderNational Science Foundation (US)-
dc.contributor.funderDepartment of Agriculture (US)-
dc.contributor.funderPurdue University-
dc.identifier.funderhttp://dx.doi.org/10.13039/100000001es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100006377es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000199es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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