Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/37774
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Narasimhan, Meena L. | - |
dc.contributor.author | Damsz, Barbara | - |
dc.contributor.author | Coca, María | - |
dc.contributor.author | Ibeas, José I. | - |
dc.contributor.author | Yun, Dae-Jin | - |
dc.contributor.author | Pardo, José M. | - |
dc.contributor.author | Hasegawa, Paul M. | - |
dc.contributor.author | Bressan, Ray A. | - |
dc.date.accessioned | 2011-07-14T13:07:29Z | - |
dc.date.available | 2011-07-14T13:07:29Z | - |
dc.date.issued | 2001-10-26 | - |
dc.identifier.citation | Molecular Cell 8(4): 921-930 (2001) | es_ES |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10261/37774 | - |
dc.description | 10 pages, 1 table, 6 figures, 56 references. | es_ES |
dc.description.abstract | Osmotin is a tobacco PR-5 protein that has antifungal activity and is implicated in host-plant defense. We show here that osmotin induces apoptosis in Saccharomyces cerevisiae. Induction of apoptosis was correlated with intracellular accumulation of reactive oxygen species and was mediated by RAS2, but not RAS1. Osmotin treatment resulted in suppression of transcription of stress-responsive genes via the RAS2/cAMP pathway. It was therefore concluded that osmotin induced proapoptotic signaling in yeast. The results indicate that the ability of antimicrobial proteins to induce microbial apoptosis could be an important factor in determining a pathogen's virulence and could therefore be targeted for the design of new antifungal drugs. | es_ES |
dc.description.sponsorship | This work was supported in part by funds from the NSF Award No. 9808551-MCB, USDA Cooperative Research Program, USDA Award No. 96-34339-3484, Bard Project No. IS-2610-95CR, and Purdue University Agricultural Experiment Station. J. I. I. was supported by a Spanish Government Fellowship. This is journal paper number 16,471 of the Purdue University Agricultural Experiment Station. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | A plant defense response effector induces microbial apoptosis | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/S1097-2765(01)00365-3 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/doi:10.1016/S1097-2765(01)00365-3 | es_ES |
dc.contributor.funder | National Science Foundation (US) | - |
dc.contributor.funder | Department of Agriculture (US) | - |
dc.contributor.funder | Purdue University | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100000001 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100006377 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000199 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IRNAS) Artículos |
CORE Recommender
SCOPUSTM
Citations
150
checked on 23-mar-2024
WEB OF SCIENCETM
Citations
141
checked on 22-feb-2024
Page view(s)
340
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.