Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37774
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Título : A plant defense response effector induces microbial apoptosis
Autor : Narasimhan, Meena L., Damsz, Barbara, Coca, María, Ibeas, José I., Yun, Dae-Jin, Pardo, José M., Hasegawa, Paul M., Bressan, Ray A.
Fecha de publicación : 26-Oct-2001
Editor: Elsevier
Citación : Molecular Cell 8(4): 921-930 (2001)
Resumen: Osmotin is a tobacco PR-5 protein that has antifungal activity and is implicated in host-plant defense. We show here that osmotin induces apoptosis in Saccharomyces cerevisiae. Induction of apoptosis was correlated with intracellular accumulation of reactive oxygen species and was mediated by RAS2, but not RAS1. Osmotin treatment resulted in suppression of transcription of stress-responsive genes via the RAS2/cAMP pathway. It was therefore concluded that osmotin induced proapoptotic signaling in yeast. The results indicate that the ability of antimicrobial proteins to induce microbial apoptosis could be an important factor in determining a pathogen's virulence and could therefore be targeted for the design of new antifungal drugs.
Descripción : 10 pages, 1 table, 6 figures, 56 references.
Versión del editor: http://dx.doi.org/doi:10.1016/S1097-2765(01)00365-3
URI : http://hdl.handle.net/10261/37774
ISSN: 1097-2765
DOI: doi:10.1016/S1097-2765(01)00365-3
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