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Closed Access item Structural basis for membrane anchorage of viral ø29 DNA during replication

Authors:Albert, Armando
Muñoz-Espín, D.
Jiménez, M.
Asensio, J. L.
Hermoso, José Miguel
Salas, Margarita
Meijer, Wilhelmus J. J.
Issue Date:30-Dec-2005
Publisher:American Society for Biochemistry and Molecular Biology
Citation:The Journal of Biological Chemistry 280: 20730-20739 (2005)
Abstract:Prokaryotic DNA replication is compartmentalized at the cellular membrane. Functional and biochemical studies showed that the Bacillus subtilis phage ϕ29-encoded membrane protein p16.7 is directly involved in the organization of membrane-associated viral DNA replication. The structure of the functional domain of p16.7 in complex with DNA, presented here, reveals the multimerization mode of the protein and provides insights in the organization of the phage genome at the membrane of the infected cell.
Publisher version (URL):http://dx.doi.org/10.1074/jbc.C500429200
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