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http://hdl.handle.net/10261/37724
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Meijer, Wilfried J. J. | - |
dc.contributor.author | Castilla, Virginia | - |
dc.contributor.author | Villar, Laurentino | - |
dc.contributor.author | Murray, H. | - |
dc.contributor.author | Errington, Jeff | - |
dc.contributor.author | Salas, Margarita | - |
dc.date.accessioned | 2011-07-13T09:24:19Z | - |
dc.date.available | 2011-07-13T09:24:19Z | - |
dc.date.issued | 2005-10-19 | - |
dc.identifier.citation | Embo Journal 24(20): 3647-3657 (2005) | es_ES |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10261/37724 | - |
dc.description | PMCID: PMC1276709 | es_ES |
dc.description.abstract | Phage ø29 is a virulent phage of Bacillus subtilis with no known lysogenic cycle. Indeed, lysis occurs rapidly following infection of vegetative cells. Here, we show that 29 possesses a powerful strategy that enables it to adapt its infection strategy to the physiological conditions of the infected host to optimize its survival and proliferation. Thus, the lytic cycle is suppressed when the infected cell has initiated the process of sporulation and the infecting phage genome is directed into the highly resistant spore to remain dormant until germination of the spore. We have also identified two host-encoded factors that are key players in this adaptive infection strategy. We present evidence that chromosome segregation protein Spo0J is involved in spore entrapment of the infected ø29 genome. In addition, we demonstrate that Spo0A, the master regulator for initiation of sporulation, suppresses ø29 development by repressing the main early ø29 promoters via different and novel mechanisms and also by preventing activation of the single late ø29 promoter. | es_ES |
dc.description.sponsorship | This investigation was supported by grants 2RO1 GM27242-24 from the National Institutes of Health and BMC2002-03818 from the Spanish Ministry of Science and Technology to MS and an Institutional grant from Fundación Ramón Areces to the Centro de Biología Molecular 'Severo Ochoa'. VC is holder of a predoctoral fellowship from the Spanish Ministry of Science and Technology, which also supported WJJM by means of the 'Ramón y Cajal' program. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Bacillus subtilis | es_ES |
dc.subject | Phage ø29 | es_ES |
dc.subject | Spo0A | es_ES |
dc.subject | Spo0J | es_ES |
dc.subject | Transcriptional regulation | es_ES |
dc.title | Molecular basis for the exploitation of spore formation as survival mechanism by virulent phage ø29 | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/sj.emboj.7600826 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/sj.emboj.7600826 | es_ES |
dc.contributor.funder | National Institutes of Health (US) | - |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100006280 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.pmid | 16193065 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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