Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37648
Share/Impact:
Título : Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Autor : Loos, Ruth J. F., Peral, Belén
Palabras clave : Genetic variation
IRS1
Fecha de publicación : 26-Jun-2011
Editor: Nature Publishing Group
Citación : Nature Genetics 43(8): 753-760 (2011)
Resumen: Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ~2.5 million SNPs and body fat percentage from 36,626 individuals and followed up the 14 most significant (P < 10−6) independent loci in 39,576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10−26) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10−11) and one near SPRY2 (P = 3 × 10−8). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat–decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.
Descripción : El pdf del artículo es el manuscrito de autor: PMC3262230.-- et al.
Versión del editor: http://dx.doi.org/10.1038/ng.866
URI : http://hdl.handle.net/10261/37648
ISSN: 1061-4036
DOI: 10.1038/ng.866
Citación : Nature Genetics 43(8): 753-760 (2011)
Appears in Collections:(IIBM) Artículos

Files in This Item:
File Description SizeFormat 
Genetic variation near IRS1.pdf1,18 MBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query


Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.