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Closed Access item Enantioselective Synthesis of Vicinal Halohydrins via Dynamic Kinetic Resolution

Authors:Ros, Abel
Magriz, Antonio
Dietrich, Hansjörg
Fernández, Rosario
Álvarez, Eleuterio
Lassaletta, José M.
Keywords:Enantioselective, Catalysts, Alpha-halo, Halohydrins, α-Halo, DKR
Issue Date:9-Dec-2005
Publisher:American Chemical Society
Citation:Organic Letters 8(1): 127-130 (2006)
Abstract:Expanding the scope of enantioselective catalysis via DKR, transfer hydrogenation of a variety of cyclic alpha-halo ketones was accomplished using the Noyori/Ikariya (R,R)- or (S,S)-I catalysts and either HCO(2)H/Et(3)N or HCO(2)Na/n-Bu(4)NBr in H(2)O/CH(2)Cl(2) as the hydrogen sources. Good yields of vicinal bromo-, chloro-, and fluorohydrins with excellent de and ee levels were achieved in most cases after a simple tuning of reaction conditions.
Description:4 páginas, 1 figura, 1 tabla, 3 esquemas.
Publisher version (URL):http://dx.doi.org/10.1021/ol052821k
Appears in Collections:(IIQ) Artículos

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