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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37646
Title: Enantioselective Synthesis of Vicinal Halohydrins via Dynamic Kinetic Resolution
Authors: Ros, Abel; Magriz, Antonio; Dietrich, Hansjörg; Fernández, Rosario; Álvarez, Eleuterio; Lassaletta, José M.
Keywords: Enantioselective
Issue Date: 9-Dec-2005
Publisher: American Chemical Society
Citation: Organic Letters 8(1): 127-130 (2006)
Abstract: Expanding the scope of enantioselective catalysis via DKR, transfer hydrogenation of a variety of cyclic alpha-halo ketones was accomplished using the Noyori/Ikariya (R,R)- or (S,S)-I catalysts and either HCO(2)H/Et(3)N or HCO(2)Na/n-Bu(4)NBr in H(2)O/CH(2)Cl(2) as the hydrogen sources. Good yields of vicinal bromo-, chloro-, and fluorohydrins with excellent de and ee levels were achieved in most cases after a simple tuning of reaction conditions.
Description: 4 páginas, 1 figura, 1 tabla, 3 esquemas.
Publisher version (URL): http://dx.doi.org/10.1021/ol052821k
URI: http://hdl.handle.net/10261/37646
ISSN: 1523-7060
DOI: 10.1021/ol052821k
References: 16381584
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