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Closed Access item Intramolecular Benzyl Protection Delivery: A Practical Synthesis of DMDP and DGDP from d-Fructose

Authors:García Moreno, María Isabel
Aguilar Moncayo, Matilde
Ortiz-Mellet, Carmen
García-Fernández, José Manuel
Keywords:Ethers, Fructose, Imino pyranoses, Mannitol, Molecular structure, Sorbitol, Glycoside hydrolases, Stereoisomerism
Issue Date:18-Dec-2005
Publisher:American Chemical Society
Citation:Organic Letters 8(2): 297-299 (2006)
Abstract:A two-step protection of 1,2-diols as the corresponding o-xylylene cyclic ethers, involving an intramolecular ring-closing O-benzylation reaction, has been developed to overcome the problems associated to regioselective benzylation reactions. The strategy has been applied to the high-yielding synthesis of the pyrrolidine glycosidase inhibitors DMDP and DGDP.
Description:3 páginas, 4 esquemas.
Publisher version (URL):http://dx.doi.org/ 10.1021/ol052668u
URI:http://hdl.handle.net/10261/37645
ISSN:1523-7060
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Appears in Collections:(IIQ) Artículos

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