Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/37623
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane |
Autor: | Gerges, Nashaat Z.; Backos, D. S.; Rupasinghe, Chamila N.; Spaller, Mark R.; Esteban, José A. CSIC ORCID | Palabras clave: | Exo70 Hippocampus Membrane trafficking Sec8 Synaptic plasticity |
Fecha de publicación: | 6-abr-2006 | Editor: | Nature Publishing Group | Citación: | EMBO Journal 25: 1623 - 1634 (2006) | Resumen: | Intracellular membrane trafficking of glutamate receptors at excitatory synapses is critical for synaptic function. However, little is known about the specialized trafficking events occurring at the postsynaptic membrane. We have found that two components of the exocyst complex, Sec8 and Exo70, separately control synaptic targeting and insertion of AMPA-type glutamate receptors. Sec8 controls the directional movement of receptors towards synapses through PDZ-dependent interactions. In contrast, Exo70 mediates receptor insertion at the postsynaptic membrane, but it does not participate in receptor targeting. Thus, interference with Exo70 function accumulates AMPA receptors inside the spine, forming a complex physically associated, but not yet fused with the postsynaptic membrane. Electron microscopic analysis of these complexes indicates that Exo70 mediates AMPA receptor insertion directly within the postsynaptic density, rather than at extrasynaptic membranes. Therefore, we propose a molecular and anatomical model that dissects AMPA receptor sorting and synaptic delivery within the spine, and uncovers new functions of the exocyst at the postsynaptic membrane. | Versión del editor: | http://dx.doi.org/10.1038/sj.emboj.7601065 | URI: | http://hdl.handle.net/10261/37623 | DOI: | 10.1038/sj.emboj.7601065 | ISSN: | 0261-4189 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
JAEsteban_EmboJ_2006.pdf | 794,19 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
65
checked on 17-mar-2024
SCOPUSTM
Citations
115
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
106
checked on 25-feb-2024
Page view(s)
336
checked on 16-abr-2024
Download(s)
267
checked on 16-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.