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http://hdl.handle.net/10261/37617
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gómez García, Marta | es_ES |
dc.contributor.author | Benito, Juan M. | es_ES |
dc.contributor.author | Gutiérrez-Gallego, Ricardo | es_ES |
dc.contributor.author | Maestre, Alfredo | es_ES |
dc.contributor.author | Ortiz-Mellet, Carmen | es_ES |
dc.contributor.author | García Fernández, José Manuel | es_ES |
dc.contributor.author | Jiménez Blanco, José L. | es_ES |
dc.date.accessioned | 2011-07-08T12:52:55Z | - |
dc.date.available | 2011-07-08T12:52:55Z | - |
dc.date.issued | 2010-02-24 | - |
dc.identifier.citation | Organic and Biomolecular Chemistry 8(8): 1849-1860 (2010) | es_ES |
dc.identifier.issn | 1177-0520 | - |
dc.identifier.other | 20449489 | - |
dc.identifier.uri | http://hdl.handle.net/10261/37617 | - |
dc.description | 12 páginas, 5 figuras, 3 tablas, 3 esquemas. | es_ES |
dc.description.abstract | A versatile synthetic procedure to construct series of high- and low-density homo- and heteroglycoclusters is reported. The binding properties of these synthetic multivalent glycoconjugates to concanavalin A (Con A), a model lectin, have been assessed by using a range of competitive and non-competitive binding assays including enzyme-linked lectin assays (ELLA), isothermal titration microcalorimetry (ITC) and surface plasmon resonance (SPR). In all cases, highly dense glycoclusters showed a substantial amplification of the lectin-binding strength in comparison with low-density counterparts. Interestingly, highly-dense glycoligand presentations, regardless of their homo- or heteroglycoligand pattern, furnished similar Con A binding properties, supporting the existence of a synergic effect (heterocluster effect) due to secondary interactions of “non-active” structural motifs in the presence of a certain density of “active” glycoligands. | es_ES |
dc.description.sponsorship | We thank the Spanish Ministerio de Educación y Ciencia (contracts number CTQ2006-15515-C02-01/BQUand CTQ2007-61180/PPQ) and the Junta de Andalucía for financial support. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry (UK) | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Carbohydrates | es_ES |
dc.subject | Glycoconjugates | es_ES |
dc.subject | Surface Plasmon Resonance | es_ES |
dc.subject | Lectins | es_ES |
dc.subject | Concanavalin A | es_ES |
dc.subject | Molecular sequence data | es_ES |
dc.title | Comparative studies on lectin–carbohydrate interactions in low and high density homo- and heteroglycoclusters | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1039/B920048G | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1039/B920048G | es_ES |
dc.relation.csic | Sí | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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