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dc.contributor.authorGómez García, Martaes_ES
dc.contributor.authorBenito, Juan M.es_ES
dc.contributor.authorGutiérrez-Gallego, Ricardoes_ES
dc.contributor.authorMaestre, Alfredoes_ES
dc.contributor.authorOrtiz-Mellet, Carmenes_ES
dc.contributor.authorGarcía Fernández, José Manueles_ES
dc.contributor.authorJiménez Blanco, José L.es_ES
dc.date.accessioned2011-07-08T12:52:55Z-
dc.date.available2011-07-08T12:52:55Z-
dc.date.issued2010-02-24-
dc.identifier.citationOrganic and Biomolecular Chemistry 8(8): 1849-1860 (2010)es_ES
dc.identifier.issn1177-0520-
dc.identifier.other20449489-
dc.identifier.urihttp://hdl.handle.net/10261/37617-
dc.description12 páginas, 5 figuras, 3 tablas, 3 esquemas.es_ES
dc.description.abstractA versatile synthetic procedure to construct series of high- and low-density homo- and heteroglycoclusters is reported. The binding properties of these synthetic multivalent glycoconjugates to concanavalin A (Con A), a model lectin, have been assessed by using a range of competitive and non-competitive binding assays including enzyme-linked lectin assays (ELLA), isothermal titration microcalorimetry (ITC) and surface plasmon resonance (SPR). In all cases, highly dense glycoclusters showed a substantial amplification of the lectin-binding strength in comparison with low-density counterparts. Interestingly, highly-dense glycoligand presentations, regardless of their homo- or heteroglycoligand pattern, furnished similar Con A binding properties, supporting the existence of a synergic effect (heterocluster effect) due to secondary interactions of “non-active” structural motifs in the presence of a certain density of “active” glycoligands.es_ES
dc.description.sponsorshipWe thank the Spanish Ministerio de Educación y Ciencia (contracts number CTQ2006-15515-C02-01/BQUand CTQ2007-61180/PPQ) and the Junta de Andalucía for financial support.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistry (UK)es_ES
dc.rightsclosedAccesses_ES
dc.subjectCarbohydrateses_ES
dc.subjectGlycoconjugateses_ES
dc.subjectSurface Plasmon Resonancees_ES
dc.subjectLectinses_ES
dc.subjectConcanavalin Aes_ES
dc.subjectMolecular sequence dataes_ES
dc.titleComparative studies on lectin–carbohydrate interactions in low and high density homo- and heteroglycoclusterses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1039/B920048G-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1039/B920048Ges_ES
dc.relation.csices_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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