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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37608
Title: Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-D-Fructose Dianhydrides (DFAs)
Authors: García Moreno, María Isabel; Benito, Juan M.; Ortiz-Mellet, Carmen; García-Fernández, José Manuel
Keywords: Spirocompounds
Stereoselective synthesis
Difructose dianhydrides
Issue Date: 12-Aug-2008
Publisher: Multidisciplinary Digital Publishing Institute
Citation: Molecules 13(8): 1640-1670 (2008)
Abstract: Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon thermal and/or acidic activation of sucroseand/ or D-fructose-rich materials. The recent discovery of the presence of DFAs in food products and their remarkable nutritional features has attracted considerable interest from the food industry. DFAs behave as low-caloric sweeteners and have proven to exert beneficial prebiotic nutritional functions, favouring the growth of Bifidobacterium spp. In the era of functional foods, investigation of the beneficial properties of DFAs has become an important issue. However, the complexity of the DFA mixtures formed during caramelization or roasting of carbohydrates by traditional procedures (up to 14 diastereomeric spiroketal cores) makes evaluation of their individual properties a difficult challenge. Great effort has gone into the development of efficient procedures to obtain DFAs in pure form at laboratory and industrial scale. This paper is devoted to review the recent advances in the stereoselective synthesis of DFAs by means of chemical and enzymatic approaches, their scope, limitations, and complementarities.
Description: 31 páginas, 15 figuras, 6 tablas, 9 esquemas.
Publisher version (URL): http://dx.doi.org/10.3390/molecules13071640
URI: http://hdl.handle.net/10261/37608
DOI: 10.3390/molecules13071640
ISSN: 10.3390/molecules13071640
References: 18794777
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