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Closed Access item Tachykinins and tachykinin receptors: effects in the genitourinary tract

Authors:Candenas de Luján, M. Luz
Lecci, Alessandro
Pinto Pérez, Francisco M.
Patak, Eva
Maggi, Carlo Alberto
Pennefather, Jocelyn N.
Keywords:Tachykinins, Tachykinin receptors, Urinary tract, Genital tract
Issue Date:7-Jan-2005
Publisher:Elsevier
Citation:Life Sciences - Kidlington 76(8): 835-862 (2005)
Abstract:Tachykinins (TKs) are a family of peptides involved in the central and peripheral regulation of urogenital functions through the stimulation of TK NK1, NK2 and NK3 receptors. At the urinary system level, TKs locally stimulate smooth muscle tone, ureteric peristalsis and bladder contractions, initiate neurogenic inflammation and trigger local and spinal reflexes aimed to maintain organ functions in emergency conditions. At the genital level, TKs are involved in smooth muscle contraction, in inflammation and in the modulation of steroid secretion by the testes and ovaries. TKs produce vasodilatation of maternal and fetal placental vascular beds and appear to be involved in reproductive function, stress-induced abortion, and pre-eclampsia. The current data suggest that the genitourinary tract is a primary site of action of the tachykininergic system.
Description:28 páginas, 2 figuras.
Publisher version (URL):http://dx.doi.org/10.1016/j.lfs.2004.10.004
URI:http://hdl.handle.net/10261/37601
ISSN:0024-3205
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Appears in Collections:(IIQ) Artículos

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