Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37578
Título : DNA bending and looping in the transcriptional control of Bacteriophage Ø29
Autor : Camacho, Ana Gema, Salas, Margarita
Palabras clave : Bacillus subtilis
Phage Ø29
Gene regulation
Transcription initiation
Transcriptional regulators
Nucleoprotein complexes
Protein-induced DNA bending
Direct and indirect readout
Fecha de publicación : 17-Mar-2010
Editor: Wiley-Blackwell
Resumen: Recent studies on the regulation of phage φ29 gene expression reveal new ways to accomplish the processes required for the orderly gene expression in prokaryotic systems. These studies revealed a novel DNA-binding domain in the phage main transcriptional regulator and the nature and dynamics of the multimeric DNA–protein complex responsible for the switch from early to late gene expression. This review describes the features of the regulatory mechanism that leads to the simultaneous activation and repression of transcription, and discusses it in the context of the role of the topological modification of the DNA carried out by two phage-encoded proteins working synergistically with the DNA.
Descripción : Work was funded by Grants BFU2008-00215/BMC to M.S. and BFU2008-01216/BMC to A.C., from the Ministerio de Ciencia e Innovación of Spain, by Grant S-0505/MAT/0283-05 to M.S. from the Madrid Autonomous Community, by the Intramural-CSIC Grant 2007 20I007 to A.C. and by an Institutional Grant from the Fundación Ramón Areces to the Centro de Biología Molecular Severo Ochoa.
Versión del editor: http://dx.doi.org/10.1111/j.1574-6976.2010.00219.x
URI : http://hdl.handle.net/10261/37578
ISSN: 0378-1097
Citación : FEMS Microbiology Letters 34(5): 828-41 (2010)
Appears in Collections:(CBM) Artículos

Files in This Item:
There are no files associated with this item.
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.