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|Title:||DNA bending and looping in the transcriptional control of Bacteriophage Ø29|
|Authors:||Camacho, Ana Gema; Salas, Margarita|
Protein-induced DNA bending
Direct and indirect readout
|Citation:||FEMS Microbiology Letters 34(5): 828-41 (2010)|
|Abstract:||Recent studies on the regulation of phage φ29 gene expression reveal new ways to accomplish the processes required for the orderly gene expression in prokaryotic systems. These studies revealed a novel DNA-binding domain in the phage main transcriptional regulator and the nature and dynamics of the multimeric DNA–protein complex responsible for the switch from early to late gene expression. This review describes the features of the regulatory mechanism that leads to the simultaneous activation and repression of transcription, and discusses it in the context of the role of the topological modification of the DNA carried out by two phage-encoded proteins working synergistically with the DNA.|
|Description:||Work was funded by Grants BFU2008-00215/BMC to M.S. and BFU2008-01216/BMC to A.C., from the Ministerio de Ciencia e Innovación of Spain, by Grant S-0505/MAT/0283-05 to M.S. from the Madrid Autonomous Community, by the Intramural-CSIC Grant 2007 20I007 to A.C. and by an Institutional Grant from the Fundación Ramón Areces to the Centro de Biología Molecular Severo Ochoa.|
|Publisher version (URL):||http://dx.doi.org/10.1111/j.1574-6976.2010.00219.x|
|Appears in Collections:||(CBM) Artículos|
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