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Cannabinoid CB1 Receptor Is Downregulated in Clear Cell Renal Cell Carcinoma

AuthorsLarrinaga, Gorka; Sanz, Begoña; Pérez, Itxaro; Blanco, Lorena; Candenas, M. Luz ; Pinto Pérez, Francisco M. ; Gil, Javier; López, José Ignacio
KeywordsClear cell renal
Cell carcinoma
Cannabionoid receptors
Western blot
Issue DateDec-2010
PublisherHistochemical Society
CitationJournal of Histochemistry and Cytochemistry 58(12): 1129-1134 (2010)
AbstractSeveral studies in cell cultures and in animal models have demonstrated that cannabinoids have important antitumoral properties. Because many of these effects are mediated through cannabinoid (CB) receptors CB1 and CB2, the study of their expression in human neoplasms has become of great interest in recent years. Fresh and formalin-fixed tissue samples of 20 consecutive clear cell renal cell carcinomas (CCRCCs) were collected prospectively and analyzed for the expression of both CB receptors by using RT-PCR, Western blot (WB), and immunohistochemical techniques. RT-PCR assays demonstrated the expression of mRNA encoding the CB1 in tumor tissue and in adjacent non-neoplastic kidney.Conversely, WB and IHC revealed a marked downregulation of CB1 protein in tumor tissue; CB2 was not expressed. The obtained data suggest a possible implication of the endocannabinoid system in renal carcinogenesis. A posttranscriptional downregulation of CB1 and the absence of expression of CB2 characterize CCRCC.
Description7 páginas, 3 figuras, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.1369/jhc.2010.957126
Appears in Collections:(IIQ) Artículos
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