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Title

Backbone dynamics of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue, by 15N NMR relaxation methods

AuthorsCanales, Ángeles ; Fayos, Rosa ; Angulo, Jesús ; Ojeda, Rafael; Martín-Pastor, Manuel; Nieto, Pedro M. ; Martín-Lomas, Manuel; Lozano, R.M. ; Giménez-Gallego, Guillermo ; Jiménez-Barbero, Jesús
KeywordsChemical shift perturbation
Fibroblast growth factors
Heparan sulfate oligosaccharides
Protein-carbohydrate interactions
Relaxation analysis
Issue Date2006
PublisherSpringer
CitationJournal of Biomolecular NMR 35(4): 225-239 (2006)
AbstractThe binding site and backbone dynamics of a bioactive complex formed by the acidic fibroblast growth factor (FGF-1) and a specifically designed heparin hexasaccharide has been investigated by HSQC and relaxation NMR methods. The comparison of the relaxation data for the free and bound states has allowed showing that the complex is monomeric, and still induces mutagenesis, and that the protein backbone presents reduced motion in different timescale in its bound state, except in certain points that are involved in the interaction with the fibroblast growth factor receptor (FGFR).
Description15 páginas, 7 figuras, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.1007/s10858-006-9024-y
URIhttp://hdl.handle.net/10261/37507
DOI10.1007/s10858-006-9024-y
ISSN0925-2738
Appears in Collections:(IIQ) Artículos
(CIB) Artículos
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