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Title

Conformational Flexibility of a Synthetic Glycosylaminoglycan Bound to a Fibroblast Growth Factor. FGF-1 Recognizes Both the 1C4 and 2SO Conformations of a Bioactive Heparin-like Hexasaccharide

AuthorsCanales, Ángeles ; Angulo, Jesús ; Ojeda, Rafael; Bruix, M. ; Fayos, Rosa ; Lozano, R.M. ; Giménez-Gallego, Guillermo ; Martín-Lomas, Manuel; Nieto, Pedro M. ; Jiménez-Barbero, Jesús
KeywordsNMR
FGF-1
Sugar
Hexasaccharide
Iduronic acid
Issue Date2-Apr-2005
PublisherAmerican Chemical Society
CitationJournal of the American Chemical Society 127(16): 5778-5779 (2005)
AbstractThe first direct NMR determination of the conformation of a conformationally flexible heparin-like hexasaccharide bound to a key receptor, FGF-1, is described. The determination has been based on the use of a 13C-labeled protein and a regular 12C sugar. FGF-1 recognizes several conformations of the iduronic moieties of the hexasaccharide. Therefore, this case is different than that described for the controversial recognition of heparin-like saccharides by AT-III, which seems to recognize just one conformation of the iduronic acid residues.
Description2 páginas, 1 figura, 1 tabla, esquemas.
Publisher version (URL)http://dx.doi.org/10.1021/ja043363y
URIhttp://hdl.handle.net/10261/37481
DOI10.1021/ja043363y
ISSN0002-7863
Appears in Collections:(IIQ) Artículos
(ICMM) Artículos
(IQFR) Artículos
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