English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37238
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Conformational Study of GPI Anchors: the Common Oligosaccharide GPI Anchor Backbone

AuthorsChevalier, Franck; López-Prados, Javier; Pérez, Serge; Martín-Lomas, Manuel; Nieto, Pedro M.
KeywordsGPI anchor
Conformational analysis
Molecular flexibility
Molecular modelling
NMR spectroscopy
Issue Date1-Jul-2005
CitationEuropean Journal of Organic Chemistry (16): 3489-3498 (2005)
AbstractThe solution three-dimensional structure of pseudopentasaccharide 6, which constitutes the product from the GPI-PLD cleavage of a GPI anchor, has been studied using a protocol which involves a systematic search of the conformational space around the glycosidic linkages, a thorough molecular dynamics study with explicit water molecules and a full NMR analysis study of intramolecular hydrogen bonding in solution. The results indicate that 6 exists in an extended conformation with a considerable flexibility compatible with a hinge-like conformational motion.
Description10 páginas, 4 figuras, 2 tablas, esquemas.
Publisher version (URL)http://dx.doi.org/10.1002/ejoc.200500171
Appears in Collections:(IIQ) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.