Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/37233
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The Synthesis and Structure of Linear and Dendritic Thiourea-Linked Glycooligomers |
Autor: | Jiménez Blanco, José L.; Bootello, Purificación; Ortiz-Mellet, Carmen; García Fernández, José Manuel CSIC ORCID | Palabras clave: | Carbohydrates Conformation analysis Dendrimers Glycooligomers Hydrogen bonding |
Fecha de publicación: | 10-nov-2005 | Editor: | Wiley-VCH | Citación: | European Journal of Organic Chemistry (1): 183-196 (2006) | Resumen: | An efficient strategy to produce unnatural glycooligomers containing thiourea intersaccharide bridges has been developed. The presence of the thiourea groups in these oligomers should promote the association with polyphosphates, including nucleic acids, due to the hydrogen-bonding capabilities of the thioureas. Moreover, glycooligomers built from thiourea groups should form complex secondary and tertiary structures due to the interplay of hydrogen bonding and rotational restriction at the bonds adjacent to thiocarbonyl groups. Herein, the preparation and conformational properties of both linear and dendritic architectures are described. This synthetic method relies on the coupling of peracetylated azidoglycosyl isothiocyanates and fully unprotected amine-functionalised growing oligomers. Deacetylation of the hemiacetylated thiourea adduct and reduction of the azido groups allow entry into a new coupling cycle. The procedure is quite general, should be easily extended to molecular diversity-oriented and solid-phase approaches and will allow the investigation of intermolecular interactions. | Descripción: | 14 páginas, 3 figuras, 6 esquemas. | Versión del editor: | http://dx.doi.org/10.1002/ejoc.200500472 | URI: | http://hdl.handle.net/10261/37233 | DOI: | 10.1002/ejoc.200500472 | ISSN: | 1434-193X | E-ISSN: | 1099-0690 |
Aparece en las colecciones: | (IIQ) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
12
checked on 07-mar-2024
WEB OF SCIENCETM
Citations
10
checked on 22-feb-2024
Page view(s)
276
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.