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dc.contributor.authorReyes-Irisarri, Elisabet-
dc.contributor.authorPérez-Torres, Silvia-
dc.contributor.authorMiró, Xavier-
dc.contributor.authorMartínez, Emili-
dc.contributor.authorPuigdomènech, Pere-
dc.contributor.authorPalacios, José M.-
dc.contributor.authorMengod Los Arcos, Guadalupe-
dc.date.accessioned2011-06-27T08:18:00Z-
dc.date.available2011-06-27T08:18:00Z-
dc.date.issued2008-01-
dc.identifier.citationSynapse 62(1): 74-79 (2008)es_ES
dc.identifier.issn0887-4476-
dc.identifier.urihttp://hdl.handle.net/10261/37166-
dc.descriptionEl pdf del artículo es la versión pre-print.es_ES
dc.description.abstractPhosphodiesterases (PDE) control intracellular cyclic adenosine monophosphate (cAMP) levels, which appear to play an important role in the regulation of inflammation. PDE4B is especially important in this process. Using in situ hybridization histochemistry we first mapped the expression sites of the four PDE4B splicing forms in rat brain. Using the systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) as an inflammation model in rats, we found an increase in PDEB2 mRNA expression in choroid plexus. The differential expression of PDE4B spliced forms and the differential regulation of PDE4B2 in an inflammatory model further supports an involvement of this splicing variant in the inflammatory response.es_ES
dc.description.sponsorshipSupported by grants awarded by Fundació La Marató de TV3; Contract gran number 1017/97, Contract grand sponsor: CICYT; Contract gran number SAF2003 -02083, SAF2006-10243). S.P.-T. and X.M. have received a fellowship from CIRIT (Generalitat de Catalunya).-
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsopenAccesses_ES
dc.subjectcAMPes_ES
dc.subjectInflammationes_ES
dc.subjectPDE4B splicing variantes_ES
dc.subjectIn situ hybridizationes_ES
dc.titleDifferential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expressiones_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/syn.20459-
dc.relation.publisherversionhttp://dx.doi.org/10.1002/syn.20459es_ES
dc.identifier.e-issn1098-2396-
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