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Open Access item Differential distribution of PDE4B splice variant mRNAs in rat brain and the effects of systemic administration of LPS in their expression

Authors:Reyes-Irisarri, Elisabet
Pérez-Torres, Silvia
Miró, Xavier
Martínez, Emili
Puigdomènech, Pere
Palacios, José M.
Mengod, Guadalupe
Keywords:cAMP, Inflammation, PDE4B splicing variant, In situ hybridization
Issue Date:Jan-2008
Publisher:Wiley-Blackwell
Citation:Synapse 62(1): 74-79 (2008)
Abstract:Phosphodiesterases (PDE) control intracellular cyclic adenosine monophosphate (cAMP) levels, which appear to play an important role in the regulation of inflammation. PDE4B is especially important in this process. Using in situ hybridization histochemistry we first mapped the expression sites of the four PDE4B splicing forms in rat brain. Using the systemic administration of the bacterial endotoxin lipopolysaccharide (LPS) as an inflammation model in rats, we found an increase in PDEB2 mRNA expression in choroid plexus. The differential expression of PDE4B spliced forms and the differential regulation of PDE4B2 in an inflammatory model further supports an involvement of this splicing variant in the inflammatory response.
Description:El pdf del artículo es la versión pre-print.
Publisher version (URL):http://dx.doi.org/10.1002/syn.20459
URI:http://hdl.handle.net/10261/37166
ISSN:0887-4476
E-ISSNmetadata.dc.identifier.doi = DOI:1098-2396
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