DSpace

Digital.CSIC > Ciencia y Tecnologías Químicas > Instituto de Investigaciones Químicas (IIQ) > (IIQ) Artículos >

Share

EndNote

Impact

Links

Closed Access item Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues

Authors:Aguilar Moncayo, Matilde
Gloster, Tracey M.
García Moreno, María Isabel
Ortiz-Mellet, Carmen
Davies, Gideon J.
Llebaria Soldevilla, Amadeu
Casas, Josefina
Egido-Gabás, Meritxell
García-Fernández, José Manuel
Keywords:Azasugars, Calystegines, Glucosidases, Iminosugars, Inhibitors
Issue Date:2-Oct-2008
Publisher:Wiley-VCH
Citation:ChemBioChem 9(16): 2612-2618 (2008)
Abstract:Neutral calystegine B2analogues, such as the 1-deoxy-6-oxa-N-(N′-octyl)thiocarbamoyl derivative, proved to be more potent β-glucosidase inhibitors than the natural alkaloid. Structural studies of the complex with a clan GH-A β-glucosidase from Thermotoga maritima showed a binding mode markedly different from that of the parent compound.
Description:7 páginas, 3 figuras, 2 tablas, 3 esquemas
Publisher version (URL):http://dx.doi.org/10.1002/cbic.200800451
URI:http://hdl.handle.net/10261/36618
ISSN:1429-4227
E-ISSNmetadata.dc.identifier.doi = DOI:1439-7633
???metadata.dc.identifier.doi???:10.1002/cbic.200800451
Appears in Collections:(IIQ) Artículos
(IQAC) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.