Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/36618
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Título : Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues
Autor : Aguilar Moncayo, Matilde, Gloster, Tracey M., García Moreno, María Isabel, Ortiz-Mellet, Carmen, Davies, Gideon J., Llebaria Soldevilla, Amadeu, Casas, Josefina, Egido-Gabás, Meritxell, García-Fernández, José Manuel
Palabras clave : Azasugars
Calystegines
Glucosidases
Iminosugars
Inhibitors
Fecha de publicación : 2-Oct-2008
Editor: Wiley-VCH
Resumen: Neutral calystegine B2analogues, such as the 1-deoxy-6-oxa-N-(N′-octyl)thiocarbamoyl derivative, proved to be more potent β-glucosidase inhibitors than the natural alkaloid. Structural studies of the complex with a clan GH-A β-glucosidase from Thermotoga maritima showed a binding mode markedly different from that of the parent compound.
Descripción : 7 páginas, 3 figuras, 2 tablas, 3 esquemas
Versión del editor: http://dx.doi.org/10.1002/cbic.200800451
URI : http://hdl.handle.net/10261/36618
ISSN: 1429-4227
DOI: 10.1002/cbic.200800451
Citación : ChemBioChem 9(16): 2612-2618 (2008)
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