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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/36618
Title: Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues
Authors: Aguilar Moncayo, Matilde; Gloster, Tracey M.; García Moreno, María Isabel; Ortiz-Mellet, Carmen; Davies, Gideon J.; Llebaria, Amadeu; Casas, Josefina; Egido-Gabás, Meritxell; García-Fernández, José Manuel
Keywords: Azasugars
Issue Date: 2-Oct-2008
Publisher: Wiley-VCH
Citation: ChemBioChem 9(16): 2612-2618 (2008)
Abstract: Neutral calystegine B2analogues, such as the 1-deoxy-6-oxa-N-(N′-octyl)thiocarbamoyl derivative, proved to be more potent β-glucosidase inhibitors than the natural alkaloid. Structural studies of the complex with a clan GH-A β-glucosidase from Thermotoga maritima showed a binding mode markedly different from that of the parent compound.
Description: 7 páginas, 3 figuras, 2 tablas, 3 esquemas
Publisher version (URL): http://dx.doi.org/10.1002/cbic.200800451
URI: http://hdl.handle.net/10261/36618
DOI: 10.1002/cbic.200800451
ISSN: 1429-4227
E-ISSN: 1439-7633
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