Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/36616
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Título : 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase
Autor : Brumshtein, Boris, Aguilar Moncayo, Matilde, García Moreno, María Isabel, Ortiz-Mellet, Carmen, García-Fernández, José Manuel, Silman, Israel, Shaaltiel, Yoseph, Aviezer, David, Sussman, Joel L., Futerman, Anthony H.
Palabras clave : Acid beta-glucosidase
Gaucher disease
Guanidine
Iminosugars
Inhibitors
Nojirimycin
Fecha de publicación : 13-May-2009
Editor: Wiley-VCH
Citación : ChemBioChem 10(9): 1480-1485 (2009)
Resumen: 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin, a reducing analogue of N-nonyl-1-deoxynojirimycin, proved to be a potent and very selective inhibitor of β-glucosidases, including human acid β-glucosidase. Structural studies of the enzyme–inhibitor complex showed a binding mode in which the anomeric hydroxy group is accommodated in the “wrong” α configuration.
Descripción : 6 páginas, 4 figuras, 2 tablas, 1 esquema
Versión del editor: http://dx.doi.org/10.1002/cbic.200900142
URI : http://hdl.handle.net/10261/36616
ISSN: 1429-4227
DOI: 10.1002/cbic.200900142
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