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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/36616
Title: 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase
Authors: Brumshtein, Boris; Aguilar Moncayo, Matilde; García Moreno, María Isabel; Ortiz-Mellet, Carmen; García-Fernández, José Manuel; Silman, Israel; Shaaltiel, Yoseph; Aviezer, David; Sussman, Joel L.; Futerman, Anthony H.
Keywords: Acid beta-glucosidase
Gaucher disease
Issue Date: 13-May-2009
Publisher: Wiley-VCH
Citation: ChemBioChem 10(9): 1480-1485 (2009)
Abstract: 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin, a reducing analogue of N-nonyl-1-deoxynojirimycin, proved to be a potent and very selective inhibitor of β-glucosidases, including human acid β-glucosidase. Structural studies of the enzyme–inhibitor complex showed a binding mode in which the anomeric hydroxy group is accommodated in the “wrong” α configuration.
Description: 6 páginas, 4 figuras, 2 tablas, 1 esquema
Publisher version (URL): http://dx.doi.org/10.1002/cbic.200900142
URI: 10261/36616
ISSN: 1429-4227
DOI: 10.1002/cbic.200900142
E-ISSN: 1439-7633
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