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Título: | Allosteric inhibition of Dictyostelium discoideum fructose-1,6-bisphosphatase by fructose 2,6-bisphosphate |
Autor: | Andrés, Vicente CSIC ORCID; García-Salguero, Leticia; Gómez, María-Esther | Palabras clave: | Fructose-1,6-bisphosphatase Fructose 2,6-bisphosphate Dictyostelium discoideum |
Fecha de publicación: | 5-dic-1998 | Editor: | Elsevier | Citación: | Febs Letters 241(1-2): 51-54 (1988) | Resumen: | It has been found that the inhibition of Dictyostelium discoideum fructose-1,6-bisphosphatase by fructose 2,6-P2 greatly diminished when the pH was raised to the range 8.5–9.5, which resulted in a marked decrease of the affinity for the inhibitor with no change in the Km for the substrate. This provides evidence for the involvement of an allosteric site for fructose 2,6-P2. Moreover, the fact that excess substrate inhibition also decreased at the pH values for minimal fructose 2,6-P2 inhibition, and was essentially abolished in the presence of fructose 2,6-P2, strongly suggests that this inhibition takes place by binding of fructose 1,6-P2 as a weak analogue of the physiological effector fructose 2,6-P2. | Descripción: | 4 páginas, 3 figuras. | Versión del editor: | http://dx.doi.org/10.1016/0014-5793(88)81029-9 | URI: | http://hdl.handle.net/10261/36375 | DOI: | 10.1016/0014-5793(88)81029-9 | ISSN: | 0014-5793 | E-ISSN: | 0892-6638 |
Aparece en las colecciones: | (IIBM) Artículos |
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