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Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation

AutorJia, Gui-Quan; Gonzalo, José Ángel; Lloyd, Clare M.; Kremer, Leonor; Lu, Lei; Martínez-Alonso, Carlos; Wershill, B.K.; Gutiérrez Ramos, José Carlos
Fecha de publicaciónnov-1996
EditorRockefeller University Press
CitaciónThe Journal of Experimental Medicine, Volume 184, November 1996 , pp.1939-1951
ResumenWe have cloned a novel mouse CC chemokine cDNA from the lung during an allergic inflammatory reaction. The protein encoded by this cDNA is chemotactic for eosinophils, monocytes, and lymphocytes in vitro and in vivo. Based on its similarities in sequence and function with other CC chemokines, we have named it mouse monocyte chemotactic protein-5 (mMCP-5). Under noninflammatory conditions, expression of mMCP-5 in the lymph nodes and thymus is constitutive and is generally restricted to stromal cells. Neutralization ofmMCP-5 protein with specific antibodies during an allergic inflammatory reaction in vivo resulted in a reduction in the number of eosinophils that accumulated in the lung. Moreover, mMCP-5 mtkNA expression in vivo is regulated differently from that of other major CC chemokines in the lung during the allergic reaction, including Eotaxin. The presence oflymphocytes is essential for expression of mMCP-5 by alveolar macrophages and smooth muscle cells in the lung, and the induction of mMCP-5 RNA occurs earlier than that of the eosinophil chemokine Eotaxin during allergic inflammation. In contrast to Eotaxin, mR.NA for mMCP-5 can be produced by mast cells. From these results, we postulate that mMCP-5 plays a pivotal role during the early stages of allergic lung inflammation.
DescripciónEl copyright pertenece a The Rockefeller University Press
URIhttp://hdl.handle.net/10261/3624
ISSN0022-1007
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