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http://hdl.handle.net/10261/3589
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Sanz, Libia | - |
dc.contributor.author | Bazaa, Amine | - |
dc.contributor.author | Marrakchi, Naziha | - |
dc.contributor.author | Pérez, Alicia | - |
dc.contributor.author | Chenik, Mehdi | - |
dc.contributor.author | Bel Lasfer, Zakaria | - |
dc.contributor.author | El Ayeb, Mohamed | - |
dc.contributor.author | Calvete, Juan J. | - |
dc.date.accessioned | 2008-04-15T11:42:48Z | - |
dc.date.available | 2008-04-15T11:42:48Z | - |
dc.date.issued | 2006-03-28 | - |
dc.identifier.citation | Biochem J. 2006 April 15; 395(Pt 2): 385–392 | en_US |
dc.identifier.issn | 1470-8728 | - |
dc.identifier.uri | http://hdl.handle.net/10261/3589 | - |
dc.description | Copyright © by Portland Press. The final version of record is available at http://www.biochemj.org/bj/default.htm | - |
dc.description.abstract | We report the cloning and sequence analysis of Cerastes vipera and Macrovipera lebetina transmediterranea cDNAs coding for short non-RGD (Arg-Gly-Asp) disintegrins and for dimeric disintegrin subunits. The mRNAs belong to the short-coding class, suggesting that these disintegrin mRNAs may be more widely distributed than previously thought. Our data also argue for a common ancestry of the mRNAs of short disintegrins and those coding for precursors of dimeric disintegrin chains. The Macrovipera lebetina transmediterranea dimeric disintegrin reported to inhibit the laminin-binding integrins α3β1, α6β1 and α7β1 was analysed using a proteomic approach and was shown to bear MLD (Met-Leu-Asp) and VGD (Val-Gly-Asp) motifs. The results highlight the fact that disintegrins have evolved a restricted panel of integrin-blocking sequences that segregate with defined branches of the phylogenetic tree of the integrin α-chains, providing novel insights into the evolutionary adaptation of the snake venom antagonists to the ligand-binding sites of their target integrin receptors. | en_US |
dc.description.sponsorship | This study has been partly financed by grant BFU2004-01432/BMC from the Ministerio de Educación y Ciencia, Madrid, Spain, and by the Spanish–Tunisian Cooperation Programme 29p/02 from the Agencia Española de Cooperación Internacional (AECI). | en_US |
dc.format.extent | 763802 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Biochemical Society | en_US |
dc.rights | openAccess | en_US |
dc.subject | Cerastes vipera | en_US |
dc.subject | Macrovipera lebetina transmediterranea | en_US |
dc.subject | Integrin inhibition | en_US |
dc.subject | Snake venom disintegrin | en_US |
dc.subject | Snake venomics | en_US |
dc.subject | Toxin evolution | en_US |
dc.title | Molecular cloning of disintegrins from Cerastes vipera and Macrovipera lebetina transmediterranea venom gland cDNA libraries: insight into the evolution of the snake venom integrin-inhibition system | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1042/BJ20051678 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.identifier.pmid | 16411889 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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