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Título: | Individual sequence variability and functional activities of fibrinogen-related proteins (FREPs) in the Mediterranean mussel (Mytilus galloprovincialis) suggest ancient and complex immune recognition models in invertebrates. |
Autor: | Novoa, Beatriz CSIC ORCID; Romero Jódar, Alejandro CSIC ORCID; Dios, S. CSIC ORCID ; Posada, David; Figueras Huerta, Antonio CSIC ORCID ; Poisa Beiro, Laura CSIC; Costa, M. M. CSIC ORCID | Palabras clave: | Fibrinogen-related proteins Ficolin Mussel Mytilus galloprovincialis FREPs |
Fecha de publicación: | 2011 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 35(3): 334-344 (2011) | Resumen: | In this paper, we describe sequences of fibrinogen-related proteins (FREPs) in the Mediterranean mussel Mytilus galloprovincialis (MuFREPs) with the fibrinogen domain probably involved in the antigen recognition, but without the additional collagen-like domain of ficolins, molecules responsible for complement activation by the lectin pathway. Although they do not seem to be true or primive ficolins since the phylogenetic analysis are not conclusive enough, their expression is increased after bacterial infection or PAMPs treatment and they present opsonic activities similar to mammalian ficolins. The most remarkable aspect of these sequences was the existence of a very diverse set of FREP sequences among and within individuals (different mussels do not share any identical sequence) which parallels the extraordinary complexity of the immune system, suggesting the existence of a primitive system with a potential capacity to recognize and eliminate different kind of pathogens. | Versión del editor: | http://dx.doi.org/10.1016/j.dci.2010.10.007 | URI: | http://hdl.handle.net/10261/35879 | DOI: | 10.1016/j.dci.2010.10.007 |
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