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dc.contributor.authorNovoa, Beatriz-
dc.contributor.authorRomero Jódar, Alejandro-
dc.contributor.authorDios, S.-
dc.contributor.authorPosada, D.-
dc.contributor.authorFigueras Huerta, Antonio-
dc.contributor.authorFigueras Huerta, Antonio-
dc.contributor.authorPoisa Beiro, Laura-
dc.contributor.authorCosta, M. M.-
dc.date.accessioned2011-05-19T16:05:03Z-
dc.date.available2011-05-19T16:05:03Z-
dc.date.issued2011-
dc.identifier.citationDevelopmental and Comparative Immunology 35(3): 334-344 (2011)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/35879-
dc.description.abstractIn this paper, we describe sequences of fibrinogen-related proteins (FREPs) in the Mediterranean mussel Mytilus galloprovincialis (MuFREPs) with the fibrinogen domain probably involved in the antigen recognition, but without the additional collagen-like domain of ficolins, molecules responsible for complement activation by the lectin pathway. Although they do not seem to be true or primive ficolins since the phylogenetic analysis are not conclusive enough, their expression is increased after bacterial infection or PAMPs treatment and they present opsonic activities similar to mammalian ficolins. The most remarkable aspect of these sequences was the existence of a very diverse set of FREP sequences among and within individuals (different mussels do not share any identical sequence) which parallels the extraordinary complexity of the immune system, suggesting the existence of a primitive system with a potential capacity to recognize and eliminate different kind of pathogens.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsopenAccesses_ES
dc.subjectFibrinogen-related proteinses_ES
dc.subjectFicolines_ES
dc.subjectMusseles_ES
dc.subjectMytilus galloprovincialises_ES
dc.subjectFREPses_ES
dc.titleIndividual sequence variability and functional activities of fibrinogen-related proteins (FREPs) in the Mediterranean mussel (Mytilus galloprovincialis) suggest ancient and complex immune recognition models in invertebrates.-
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.dci.2010.10.007-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.dci.2010.10.007-
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