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Closed Access item Novel analogues of the anti HIV-1 agent TSAO-T modified at the 3'-spiro moiety

Authors:Alvarez, Rosa
Jimeno, M. Luisa
De Clercq, Erik
Balzarini, Jan
Camarasa, María José
Issue Date:1997
Publisher:Taylor & Francis
Citation:Nucleosides, Nucleotides and Nucleic Acids16(7 & 9) : 1033 - 1036 (1997)
Abstract:Novel TSAO-T analogues, in which the 3'-spiroaminooxatioledioxide moiety has been replaced by other 3'-spiro moieties bearing a NH group at the same position as the 4''-NH2 of TSAO-T have been prepared and evaluated for their inhibitory effect on HIV replication in cell culture. In contrast to the prototype compound TSAO-T, the novel TSAO derivatives were inactive at subtoxic concentrations.
Publisher version (URL):http://dx.doi.org/10.1080/07328319708006126
URI:http://hdl.handle.net/10261/35847
ISSN:0732-8311
Appears in Collections:(CENQUIOR) Artículos

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