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Título: | Brain mitochondrial alterations after chronic alcohol consumption |
Autor: | Fernández, Anna; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; Romero, F. J. | Palabras clave: | Alcohol Mitochondria Brain Glutathione Cholesterol Rat Apoptosis |
Fecha de publicación: | sep-2009 | Editor: | Springer Nature | Citación: | Journal of Physiology and Biochemistry 65(3): 305-312 (2009) | Resumen: | The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins. | Descripción: | et al. | Versión del editor: | http://dx.doi.org/10.1007/BF03180583 | URI: | http://hdl.handle.net/10261/35177 | DOI: | 10.1007/BF03180583 | ISSN: | 1138-7548 | E-ISSN: | 1877-8755 |
Aparece en las colecciones: | (IIBB) Artículos |
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