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Título: | Decreased plasma serotonin in melancholic patients: a study with clomipramine |
Autor: | Sarrias, María José; Artigas, Francesc CSIC ORCID; Martínez, Emili CSIC ORCID; Álvarez, Enric; Udina, Claudi; Casas Brugué, Miquel | Fecha de publicación: | dic-1987 | Editor: | Elsevier | Citación: | Biological Psychiatry 22 (12) : 1429-1438 (1987) | Resumen: | Eighteen unmedicated patients suffering from major depressive disorder with melancholia (DSM-III) were examined for abnormalities in peripheral serotonin (5-HT) and related metabolites. Serotonin in platelet-free plasma and in platelets from melancholies was significantly reduced to 30% and 60% of their respective control values. Plasma 5-hydroxyindoleacetic acid was also found to be reduced, but not significantly. Other plasma compounds related to 5-HT (indoleacetic acid, total tryptophan, and free tryptophan) were found to be unchanged in these patients. Of all variables, only platelet 5-HT was affected while patients were on clomipramine (CIM) treatment. After 2 weeks on CIM (100–150 mg/day, orally), platelet 5-HT was reduced to 8% of pretreatment values, but plasma 5-HT did not change and continued to be reduced upon clinical recovery. The existence of a distinct pool of plasma 5-HT that is clearly independent of the platelet pool is indicated by the differences observed in plasma and platelet 5-HT during CIM treatment, as well as by previous data from this laboratory. The very marked decrease in plasma 5-HT levels may be in accord with the central nervous system changes reported in depression and suggests the possibility of using plasma 5-HT as a peripheral indicator of abnormal serotonin function in melancholia. | Versión del editor: | http://dx.doi.org/10.1016/0006-3223(87)90100-4 | URI: | http://hdl.handle.net/10261/34849 | DOI: | 10.1016/0006-3223(87)90100-4 | ISSN: | 0006-3223 | E-ISSN: | 1873-2402 |
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