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Título: | Analysis, accumulation and central effects of trihalomethanes. I. bromoform |
Autor: | Parra, P. CSIC; Martínez, Emili CSIC ORCID; Suñol, Cristina CSIC ORCID ; Tusell, Josep Maria CSIC; Gelpí, Emili CSIC; Artigas, Francesc CSIC ORCID | Palabras clave: | Trihalomethanes Bromoform Central nervous system Neuro-toxicology Potable water |
Fecha de publicación: | 1988 | Editor: | Taylor & Francis | Citación: | Toxicological and Environmental Chemistry 11 (2) : 79-91 (1988) | Resumen: | The paper presents the results obtained in a study on the effects of organic micropollutants on the central nervous system of the rat, used herein as a suitable model for neurotoxicologic work. Bromoform, a member of the trihalomethane (THM) family, was the pollutant selected since it becomes a characteristic marker in the Barcelona potable water supply. Analytical data on the GC-ECD separation of THMs from other volatile halocarbons is presented. A mixed packed column 10% SE-30/PEG 20M (94:6) at 70°C provides an adequate separation. The distribution of bromoform in rat plasma and tissues showed an accumulation in brain, kidney and fat, increasing in this order and a rapid elimination after 30 min. The effect on the central aminergic metabolism is studied by HPLC. The increased metabolic activity detected could be attributed either to an increased nervous activity, stimulating the metabolism of serotonin, or to its greater degradation. | Versión del editor: | http://dx.doi.org/10.1080/02772248609357122 | URI: | http://hdl.handle.net/10261/34845 | DOI: | 10.1080/02772248609357122 | ISSN: | 0277-2248 | E-ISSN: | 1029-0486 |
Aparece en las colecciones: | (IIBB) Artículos |
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