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Closed Access item Analysis, accumulation and central effects of trihalomethanes. I. bromoform

Authors:Parra, P.
Martínez, Emili
Suñol, Cristina
Tusell, Josep Maria
Gelpí, Emili
Artigas, Francesc
Keywords:Trihalomethanes, Bromoform, Central nervous system, Neuro-toxicology, Potable water
Issue Date:1988
Publisher:Taylor & Francis
Citation:Toxicological and Environmental Chemistry 11 (2) : 79-91 (1988)
Abstract:The paper presents the results obtained in a study on the effects of organic micropollutants on the central nervous system of the rat, used herein as a suitable model for neurotoxicologic work. Bromoform, a member of the trihalomethane (THM) family, was the pollutant selected since it becomes a characteristic marker in the Barcelona potable water supply. Analytical data on the GC-ECD separation of THMs from other volatile halocarbons is presented. A mixed packed column 10% SE-30/PEG 20M (94:6) at 70°C provides an adequate separation. The distribution of bromoform in rat plasma and tissues showed an accumulation in brain, kidney and fat, increasing in this order and a rapid elimination after 30 min. The effect on the central aminergic metabolism is studied by HPLC. The increased metabolic activity detected could be attributed either to an increased nervous activity, stimulating the metabolism of serotonin, or to its greater degradation.
Publisher version (URL):http://dx.doi.org/10.1080/02772248609357122
E-ISSNmetadata.dc.identifier.doi = DOI:1029-0486
Appears in Collections:(IIBB) Artículos

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