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Título: | Regional distribution of extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain of freely moving rats. |
Autor: | Adell, Albert CSIC ORCID ; Carceller, Alicia; Artigas, Francesc CSIC ORCID | Palabras clave: | 5-hydroxytryptamine Intracerebral microdialysis Regional distribution Raphe |
Fecha de publicación: | feb-1991 | Editor: | John Wiley & Sons | Citación: | Journal of Neurochemistry 56 (2) : 709-712 (1991) | Resumen: | The extracellular concentrations of 5-hydroxytryptamine (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) have been determined in six brain areas of awake rats (frontal cortex, striaturn, hypothalamus, hippocampus, inferior colliculus, and raphe nuclei) using intracerebral microdialysis. The extracellular levels of 5-HT showed no significant differences among the brain regions studied. The tissue levels of 5-HT and 5-HIAA as well as the extracellular concentration of 5-HIAA were significantly higher in raphe nuclei. The regional distribution of tissue and extracellular 5-HIAA were very similar, suggesting that extracellular 5-HIAA depends mainly on the output from the intracellular compartment. On the other hand, extracellular 5-HT and tissue 5-HT showed a different distribution pattern. The tissue/extracellular ratio for 5-HT ranged from 739 in frontal cortex to 2,882 in raphe, whereas it only amounted to 1.8–3.6 for 5-HIAA. The relationship between the present results and the density of 5-HT uptake sites in these areas is discussed. | Versión del editor: | http://dx.doi.org/10.1111/j.1471-4159.1991.tb08208.x http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1991.tb08208.x/abstract |
URI: | http://hdl.handle.net/10261/34806 | DOI: | 10.1111/j.1471-4159.1991.tb08208.x | ISSN: | 0022-3042 | E-ISSN: | 1471-4159 |
Aparece en las colecciones: | (IIBB) Artículos |
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