Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/34780
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Effects of chronic treatment with dexfenfluramine on serotonin in rat blood, brain and lung tissue |
Autor: | Celada, Pau CSIC ORCID; Martín, Francisco; Artigas, Francesc CSIC ORCID | Palabras clave: | Dexfenfluramine Serotonin Blood Lungs Brain |
Fecha de publicación: | 1994 | Editor: | Elsevier | Citación: | Life Sciences - Kidlington 55 (15) : 1237-1243 (1994) | Resumen: | We have examined the effects of continuous treatment (0.5, 1, 2.5 and 5 mg·kg−1·day−1 for 14 days, using minipumps) with dexfenfluramine (dF) on the concentration of serotonin (5-hydroxytryptamine, 5-HT) in blood, lungs and brain frontal cortex. 5-HT concentration was decreased in whole blood and tissues by the two higher doses (2.5 and 5 mg·kg−1·day−1). The concentration of dF in plasma was above detection limit only in these two treatment groups. The concentration of 5-HT in plasma (extracellular) was not modified dose-dependently, although values higher than controls were noted in the 2.5 mg·kg−1 group. Significant correlations were observed between the concentration of 5-HT in whole blood and that of 5-HT (and 5-HT + 5-HIAA) in frontal cortex. Both correlated inversely with the plasma concentration of dF. These results show that treatment with dF for two weeks reduces the concentration of intracellular 5-HT in peripheral stores (platelets, lung endothelial cells) without a concurrent increase of the extracellular 5-HT pool in blood. Correlation data suggest that whole blood 5-HT content may have a predictive value of dF-induced reductions of 5-HT in brain tissue after long-term treatment. | Versión del editor: | http://dx.doi.org/10.1016/0024-3205(94)00663-6 | URI: | http://hdl.handle.net/10261/34780 | DOI: | 10.1016/0024-3205(94)00663-6 | ISSN: | 0024-3205 | E-ISSN: | 1879-0631 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
43
checked on 01-abr-2024
WEB OF SCIENCETM
Citations
42
checked on 26-feb-2024
Page view(s)
325
checked on 22-abr-2024
Download(s)
107
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.