Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/34766
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Differential effects of ipsapirone on 5-HT release in the dorsal and median raphe neuronal pathways |
Autor: | Casanovas, Josep M.; Artigas, Francesc CSIC ORCID | Palabras clave: | 5-Hydroxytryptamine (5-HT) release 5-Hydroxytryptamine1A agonists Dorsal raphe nucleus Median raphe nucleus |
Fecha de publicación: | nov-1996 | Editor: | John Wiley & Sons | Citación: | Journal of Neurochemistry 67 (5) :1945-1952 (1996) | Resumen: | Serotonergic neurons of the dorsal and median raphe nuclei are morphologically dissimilar. Recent results challenge previous evidence indicating a greater inhibition of dorsal raphe neurons after 5-hydroxytryptamine1A (5-HT1A) autoreceptor activation. As both nuclei innervate different forebrain territories, this issue is critical to understanding the changes in brain function induced by anxiolytic and antidepressant drugs. Using microdialysis, we examined the modifications of 5-HT release induced by the selective 5-HT1A agonist ipsapirone in both neuronal pathways. Maximal and minimal basal 5-HT values (in the presence of 1 µM citalopram) were 45.0 ± 4.8 fmol/fraction in the median raphe nucleus and 8.4 ± 0.4 fmol/fraction in the dorsal hippocampus. Ipsapirone (0.3, 3, and 10 mg/kg s.c.) reduced dose-dependently 5-HT in the two raphe nuclei and four forebrain areas. Maximal reductions (to ∼25% of predrug values) were observed in cortex and striatum and in median raphe nucleus. The effects were more moderate in dorsal and ventral hippocampus (to 66 and 50% of baseline, respectively). These results are consistent with a higher sensitivity of dorsal raphe neurons to 5-HT1A autoreceptor activation. Yet the differential reduction of 5-HT release in the median raphe nucleus and hippocampus suggests the presence of complex mechanisms of control of 5-HT release in these neurons. | Versión del editor: | http://dx.doi.org/10.1046/j.1471-4159.1996.67051945.x | URI: | http://hdl.handle.net/10261/34766 | DOI: | 10.1046/j.1471-4159.1996.67051945.x | ISSN: | 0022-3042 | E-ISSN: | 1471-4159 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
70
checked on 18-abr-2024
Page view(s)
263
checked on 19-abr-2024
Download(s)
84
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.