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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/34764
Title: Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists
Authors: Artigas, Francesc; Romero, Luz; Montigny, Claude de; Blier, Pierre
Keywords: Antidepressants
Dorsal raphe nucleus
5-HT1a antagonists
Issue Date: Sep-1996
Publisher: Elsevier
Citation: Trends in Neurosciences 19 (9) : 378-383 (1996)
Abstract: At clinically relevant doses, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and MAO inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphé nuclei, thereby activating inhibitory somatodendritic 5-HT1A autoreceptors. Consequently, the firing activity of 5-HT neurons is reduced and the enhancement of extracellular 5-HT concentration in forebrain is dampened. Overriding this feedback by using antagonists of 5-HT1A autoreceptors permits SSRIs to produce a marked increase of extracellular 5-HT in the forebrain. Hence, combined treatment with an SSRI and a 5-HT1A antagonist increases the extracellular concentration of 5-HT more so than the former drug alone. The treatment of patients with major depression using an SSRI and pindolol, a 5-HT1A/β-adrenoceptor antagonist, markedly reduced the latency of the antidepressant response in previously untreated patients and induced a rapid improvement in treatment-resistant patients.
Publisher version (URL): http://dx.doi.org/10.1016/S0166-2236(96)10037-0
URI: http://hdl.handle.net/10261/34764
ISSN: 0166-2236
DOI: 10.1016/S0166-2236(96)10037-0
E-ISSN: 1878-108X
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