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Title

Branched RNA: A New Architecture for RNA Interference

AuthorsAviñó, Anna ; Ocampo, Sandra M. ; Perales, José Carlos; Eritja Casadellà, Ramón
Issue DateMar-2011
PublisherHindawi Publishing Corporation
CitationJournal of Nucleic Acids 2011: 586935 (2011)
AbstractBranched RNAs with two and four strands were synthesized. These structures were used to obtain branched siRNA. The branched siRNA duplexes had similar inhibitory capacity as those of unmodified siRNA duplexes, as deduced from gene silencing experiments of the TNF-α protein. Branched RNAs are considered novel structures for siRNA technology, and they provide an innovative tool for specific gene inhibition. As the method described here is compatible with most RNA modifications described to date, these compounds may be further functionalized to obtain more potent siRNA derivatives and can be attached to suitable delivery systems.
Description7 páginas, 6 figuras, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.4061/2011/586935
URIhttp://hdl.handle.net/10261/34728
DOI10.4061/2011/586935
ISSN2090-0201
Appears in Collections:(IQAC) Artículos
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