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dc.contributor.authorLaayouni, Hafid-
dc.contributor.authorMontanucci, Ludovica-
dc.contributor.authorSikora, Martin-
dc.contributor.authorMelé, Marta-
dc.contributor.authorDall'Olio, Giovanni Marco-
dc.contributor.authorLorente-Galdós, Belén-
dc.contributor.authorMcGee, Kate M.-
dc.contributor.authorGraffelman, Jan-
dc.contributor.authorAwadalla, Philip-
dc.contributor.authorBosch, Elena-
dc.contributor.authorComas, David-
dc.contributor.authorNavarro, Arcadi-
dc.contributor.authorCalafell, Francesc-
dc.contributor.authorCasals, Ferran-
dc.contributor.authorBertranpetit, Jaume-
dc.date.accessioned2011-04-15T13:09:53Z-
dc.date.available2011-04-15T13:09:53Z-
dc.date.issued2011-03-
dc.identifier.citationPLoS ONE 6(3): e17913 (2011)es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10261/34725-
dc.description8 páginas, 3 figuras, 4 tablas.es_ES
dc.description.abstractRecombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We calculated the recombination rates between adjacent pairs of 636,933 common single-nucleotide polymorphism loci in 28 worldwide human populations and analyzed them in relation to genetic distances between populations. We found a strong and highly significant correlation between similarity in the recombination rates corrected for effective population size and genetic differentiation between populations. This correlation is observed at the genome-wide level, but also for each chromosome and when genetic distances and recombination similarities are calculated independently from different parts of the genome. Moreover, and more relevant, this relationship is robustly maintained when considering presence/absence of recombination hotspots. Simulations show that this correlation cannot be explained by biases in the inference of recombination rates caused by haplotype sharing among similar populations. This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans.es_ES
dc.description.sponsorshipThis research was funded by grants BFU2007-63657, BFU2009-13409-C02-02 and SAF-2007-63171 awarded by Ministerio de Educación y Ciencia (Spain), by the Direcció General de Recerca of Generalitat de Catalunya (Grup de Recerca Consolidat 2005SGR/00608 and 2009 SGR 1101), and by the National Institute for Bioinformatics (www.inab.org), a platform of Genoma España.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher’s version-
dc.rightsopenAccesses_ES
dc.titleSimilarity in Recombination Rate Estimates Highly Correlates with Genetic Differentiation in Humanses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0017913-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0017913es_ES
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