DSpace

Digital.CSIC > Recursos Naturales > Instituto de Biología Evolutiva (IBE) > (IBE) Artículos >

Share

EndNote

Impact

Open Access item Similarity in Recombination Rate Estimates Highly Correlates with Genetic Differentiation in Humans

Authors:Laayouni, Hafid
Montanucci, Ludovica
Sikora, Martin
Melé, Marta
Dall'Olio, Giovanni Marco
Lorente-Galdós, Belén
McGee, Kate M.
Graffelman, Jan
Awadalla, Philip
Bosch, Elena
Comas, David
Navarro, Arcadi
Calafell, Francesc
Casals, Ferran
Bertranpetit, Jaume
Issue Date:Mar-2011
Publisher:Public Library of Science
Citation:PLoS ONE 6(3): e17913 (2011)
Abstract:Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution of recombination. Here, we analyze its recent evolution in humans. We calculated the recombination rates between adjacent pairs of 636,933 common single-nucleotide polymorphism loci in 28 worldwide human populations and analyzed them in relation to genetic distances between populations. We found a strong and highly significant correlation between similarity in the recombination rates corrected for effective population size and genetic differentiation between populations. This correlation is observed at the genome-wide level, but also for each chromosome and when genetic distances and recombination similarities are calculated independently from different parts of the genome. Moreover, and more relevant, this relationship is robustly maintained when considering presence/absence of recombination hotspots. Simulations show that this correlation cannot be explained by biases in the inference of recombination rates caused by haplotype sharing among similar populations. This result indicates a rapid pace of evolution of recombination, within the time span of differentiation of modern humans.
Description:8 páginas, 3 figuras, 4 tablas.
Publisher version (URL):http://dx.doi.org/10.1371/journal.pone.0017913
URI:http://hdl.handle.net/10261/34725
ISSN:1932-6203
???metadata.dc.identifier.doi???:10.1371/journal.pone.0017913
Appears in Collections:(IBE) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.